miR-124-3p alleviated the progress of Colorectal carcinoma

Abstract

Colorectal cancer is a common malignancy worldwide, and its incidence and mortality rates are increasing at an increasing rate. The common treatment for colorectal cancer is surgery, followed by radiotherapy and chemotherapy, but early and accurate diagnosis is a prerequisite for the treatment of the disease. Tumor signatures of colon cancer are important in the diagnosis of colon cancer. we found miR-124-3p was lower expressed in tissues of colorectal cancer, and it hampered the cell proliferation, apoptosis inhibition, migration, and invasion of colorectal cancer cell lines, and miR-124-3p overexpression hampered the tumor growth in vivo. In conclusion, miR-124-3p served as a tumor suppressor in colorectal cancer by hampered the cell proliferation, apoptosis inhibition, migration, and invasion of colorectal cancer cell lines, and miR-124-3p overexpression hampered the tumor growth in vivo. It can be a potential biomarker for early diagnosis of colorectal cancer to provide innovative ideas and methods for the diagnosis and treatment of colorectal cancer.